Selenium Protective Activity Against Aflatoxin B1 Adverse Affects on Drosophila melanogaster

نویسنده

  • Handan Uysal
چکیده

The aim of this work was to investigate the effects of AFB1 and AFB1+Se 4+ on various developmental stages of Drosophila melanogaster were investigated. Both different concentrations of AFB1 and Se 4+ applied with AFB1 were fed during the flies developmental period (egg, larva and pupae). When F1 progeny of control and application groups were compared with each other, AFB1 was found to have extending the process of metamorphosis and decreasing the total number of offsprings. But, these negative effects were inhibited with selenium treatment at different concentrations (4.0 and 8.0 ppm). These results suggested that selenium could effectively inhibit AFB1induced abnormalities of the developmental stages of D.melanogaster.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Protective and Detoxifying Effects Conferred by Dietary Selenium and Curcumin against AFB1-Mediated Toxicity in Livestock: A Review

Aflatoxin B1 (AFB1), among other aflatoxins of the aflatoxin family, is the most carcinogenic and hazardous mycotoxin to animals and human beings with very high potency leading to aflatoxicosis. Selenium is an essential trace mineral possessing powerful antioxidant functions. Selenium is widely reported as an effective antioxidant against aflatoxicosis. By preventing oxidative liver damage, sup...

متن کامل

The Effects of Sodium Humate and Aflatoxin B1 on Body Weight of Broiler Chicks

The objective of this study was to investigate the protective effect of dietary natural sorbent-sodium humate (HuNa) on the prevention of aflatoxin B1 (AFB1) toxicity in the broiler chicken. Seventy-two (72) broiler hybrid Hybro birds were randomly divided into 4 groups: control group (G1) and 3 experimental groups (G2-G4) with addition of HuNa (G2); only AFB1 (G3) and HuNa; and AFB1 (G4). HuNa...

متن کامل

Aconitase and Developmental EndPointsasEarly IndicatorsofCellularToxicity Induced by Xenobiotics in Drosophila Melanogaster

Background: In this study, the toxicity of the different xenobiotics was tested on the fruit fly Drosophila melanogaster model system.  Methods: Fly larvae were raised on food supplemented with xenobioticsat different concentrations (sodium nitroprusside (0.1-1.5 mM), S-nitrosoglutathione (0.5-4 mM), and potassium ferrocyanide (1 mM)). Emergence of flies, food intake by larvae, and pupation h...

متن کامل

Protection conferred by selenium deficiency against aflatoxin B1 in the rat is associated with the hepatic expression of an aldo-keto reductase and a glutathione S-transferase subunit that metabolize the mycotoxin.

Fischer 344 rats fed on a diet that is deficient in selenium are more resistant to the hepatocarcinogen aflatoxin B1 (AFB1) than those fed on a selenium-sufficient diet. Hepatic cytosol from either selenium-deficient Fischer 344 rats or Hooded Lister rats possesses a marked increase in both reductase activity toward AFB1-dialdehyde and glutathione S-transferase (GST) activity toward AFB(1)-8,9-...

متن کامل

Antimutagenic Effect of Resveratrol

LANGOVÁ M., POLÍVKOVÁ Z., ŠMERÁK P., BÁRTOVÁ J., BÁRTA I. (2005): Antimutagenic effect of resveratrol. Czech J. Food Sci., 23: 202–208. Evidence exist from population-based and laboratory studies that some phytochemicals have protective effects against tumors or other diseases and reveal antimutagenic activity. We studied the protective effect of the plant phytoallexin resveratrol on the mutage...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2005